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This is a complex question, but I'll share some things we know so far. First off, topical finasteride is not FDA approved for hair loss. Any use is off label. I'm going to limit all discussions here to men as use in women is not FDA approved. Is topical finasteride safer? Does it get absorbed? Well, it ALL propecia topical comes down to the dose. Yes, it gets absorbed into the blood and yes it lowers DHT levels. 1 finasteride topical solution is going to have different effects than an 8 solution..25 finasteride is going to be different yet! If I were to make. Finasteride topical solution, it would likely be quite safe with little if an absorption. However, it probably wouldn't propecia topical do anything for patients with hair loss. So it comes down to dose. One should not talk about topical finasteride unless they are prepared to talk about the dose. So let's talk about what we do know. A study.25 topical finasteride reduced DHT levels to the same amount as standard 1 mg finasteride. We don't propecia topical yet have any data to know if this translates into it working just as good, worse or better. What about side effects? We don't know that propecia topical either. If sexual performance and mood levels are related to DHT then it's pretty likely that lots of men using topical finasteride would be expected to have side effects too. These studies have not been done and we don't know. For hair loss in men, propecia topical it appears that it comes down to inhibiting DHT. Inhibit it more and you'll get a better outcome for hair loss and you'll get more side effects too.